Manmangler
Well-Known Member
Not entirely correct. You CAN remove or change mods during a playthrough. However, should you? Not necessarily, and if you don't know what you're doing to a huge degree, you shouldn't. Just find some mods you want to use, and stick with them.
It's also worth noting that even some mods cannot/shouldn't be added during a playthrough, such as Civil War Overhaul.
It depends on mods. Any mods that use active scripts running, leaves those scripts running in save game. In Fallout3/Oblivion/FNV, usually removing mods disable those scripts from save games. Easy way to break saves is activate new mods and disable then afterwards.
Even some items may leave game after mod is removed.