Kraad Vestru
Member
Not if the Dragonborn wipes out the Dark Brotherhood. Sure, Cicero may still be alive, but he won't do anything without a Listener.
If Babette's still alive (depending on if her absence from the Sanctuary is "canon" or simply to avoid killing a "child"), I have my doubts that she'd ever be given the job to kill the emperor unless she strong-armed someone to get it (and how would she do that if she wasn't ever aware of the contract?). All this assumes, too, that she doesn't just give up on the Dark Brotherhood entirely.
Just because the Dragonborn wipes them out in Skyrim doesn't mean they are gone for good. I highly doubt a group such as the Dark Brotherhood has lost entire chapters before and not fulfilled the outstanding contracts. Otherwise they would not even exist because no one would use them if they let something like the death of most of it's chapter members killed get in the way of it's targets and the Thalmor would profit too much by his death. I see no way Titus Mede II could live out the next few years regardless if the Dragonborn isn't the one that finishes him off or not. Too many people want him dead.